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KMID : 0376419890130020155
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Chonbuk University Medical Journal
1989 Volume.13 No. 2 p.155 ~ p.158
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A Study of the Effect of Antiallergic Drug in Respiratory Disease
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Abstract
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Bronchial challenge of allergen (ovalbumin)-sensitized guinea pigs induced a triphasic reduction in specific airways conductance (sGaW) with maximal reductions being observed at 2, 17 and 72hr. accompanied by infiltration of the airways with neutrophils at 17hr. and eosinophils at 17 and 72hr.. Nedocromil sodium (100mg m-1) inhaled before challenge inhibited the 2 and 17hr. sGaw response and the neutrophil influx. When inhaled 6hr. after challenge, Nedocromil inhibited the 17hr. sGaw esponse but not neutrophil influx.
The sGaw response and eosinophil accumulation at 72hr. was also inhibited by Nedocromil given at this time. We suggest that Nedocromil sodium inhibit early and late asthmatic reaction and cellular infiltration provoked by allergen challenged guinea-pigs, and being of action of anti-asthmatic drug.
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